Chromatography Equipments
Suitable for process development and small amount preparation.
High degree of automation; manual mode, method mode or procedure can be choosed.
Automatic collector is optional, supporting multiple collection modes.
High, medium and low configurations meet different customer needs.
| Names | BPHD D1 050 | BPHD D1 100 |
|---|---|---|
| Flow Rate | 0.1~50 ml/min | 0.1~100 ml/min |
| Pumps | System pump A & B; sample pump S is optional | |
| Inlet Valves | 1, 2 or 8 inlets per pump | |
| Injection Valve | Load/Inject/Waste | |
| Column Valve | Downflow / Upflow / Bypass; 1 or 8 column positions | |
| Outlet Valve | 1, 2 or 8 outlets | |
| Pressure Sensors | Pump pressure / Pre-column pressure / Post-column pressure | |
| pH Range | 0~14 | |
| Conductivity Range | 0~300 mS/cm/0~500/mS/cm | |
| UV Detecter | 200~400 nm; variable dual wavelengthes | |
| Collection Modes | Fixed volume collection / peak collection | |
| Operating Pressure Max | 50 bar | |
| Software | Puriver™ | |
Desktop design, small floor area and convenient transportation.
Equipped with solenoid valves, minimum dead volume design.
High degree of automation, flexible configurations, stable and reliable performance.
Strong compatibility, can match lab-scale and production-scale columns.
| Names | BPHD C1 0600 | BPHD C1 1000 |
|---|---|---|
| Flow Rate | 1~600 ml/min | 1~1000 ml/min |
| Pumps | Single pump / Double pumps/ Three pumps(Independent sample pump) | |
| Inlet Valves | 4 or 6 inlets per pump | |
| Air Trap Valve | Inline / Bypass; equipped with high and low level gauges | |
| Column Valve | Downflow / Upflow / Bypass; 1 column position | |
| Outlet Valve | 2, 4 or 6 outlets | |
| Pressure Sensors | Pump pressure / Pre-column pressure / Post-column pressure | |
| pH Range | 0~14 | |
| Conductivity Range | 0~300 mS/cm/0~500/mS/cm | |
| UV Detecter | 200~400 nm; fixed single wavelength or variable dual wavelengthes | |
| Operating Pressure Max | 20 bar | |
| Software | Puriver™ | |
316L and PP pipe are optional, hygienic design, meets the requirements of GMP regulations
Flexible configurations, minimum dead volume design.
Perfect authority management, audit tracking and electronic signature,meets the requirements of 21 CFR Part 11.
Data and logs are recorded in real time, which can be backed up and traceable.
Complete IQ / OQ documents and services.
Method editor function is flexible, sets of method templates are provided.
Materials conform to USP class IV, protection grade IP65.
| Names | BPHD E1 01 | BPHD E1 03 | BPHD E1 10 | BPHD E1 20 |
|---|---|---|---|---|
| Flow Rate | 0.02~1 L/min | 0.10~3 L/min | 0.26~10 L/min | 1~20 L/min |
| Pipe I.D.(mm) | 4 | 6 | 10 | 15 |
| Pumps | Single pump / Double pumps | |||
| Inlet Valves | 2, 4 or 6 inlets per pump | |||
| Air Trap Valve | Inline / Bypass; equipped with high and low level gauges | |||
| Column Valve | Downflow / Upflow / Bypass; 1 column position | |||
| Outlet Valve | 2, 4 or 6 outlets | |||
| Pressure Sensors | Pump pressure / Pre-column pressure | |||
| pH Range | 0~14 | |||
| Conductivity Range | 0~300 mS/cm/0~500/mS/cm | |||
| UV Detecter | 200~400 nm; fixed single wavelength or variable dual wavelengthes | |||
| Operating Pressure Max | 5 bar | |||
| Software | Puriver™ | |||
Desktop design, meets the requirements of GMP regulations, stable performance.
Flowmeter controls pump speed accurately and reliably；the pressure, pH,conductivity, UV and other signals are recorded in real time.
The air trap status (inline or bypass) and the column status (downflow, upflow or bypass) can be switched manually.
Perfect authority management, audit tracking and electronic signature meets the requirements of 21 CFR Part 11.
| Names | BPHD B1 01 | BPHD B1 03 | BPHD B1 10 | BPHD B1 20 |
|---|---|---|---|---|
| Flow Rate | 0.05~1 L/min | 0.15~3 L/min | 0.5~10 L/min | 1~20 L/min |
| Pipe I.D.(mm) | 4 | 6 | 10 | 15 |
| Pumps | Single pump | |||
| Inlet & Outlet | 1 inlet, 1 outlet | |||
| Air Trap Valve | Inline / Bypass; manual control | |||
| Column Valve | Downflow / Upflow / Bypass; 1 column position; manual control | |||
| pH Range | 0~14 | |||
| Conductivity Range | 0~300 mS/cm/0~500/mS/cm | |||
| UV Detecter | 200~400 nm; fixed single wavelength or variable dual wavelengthes | |||
| Operating Pressure Max | 5bar | |||
| Software | Puriver™ | |||
Various types of single-use pump heads and flow paths are optional, which are delivered gamma-irradiated sterilization, can be used for different scales from pilot-scale to production-scale.
The whole flow path is upflow, which is convenient for bubble removal; the air trap is equipped with liquid level gauges and flow paths are equipped with air sensors to effectively prevent bubbles from entering columns.
The column status (downflow, upflow or bypass) can be switched according to the need, and the system inlets and outlets numbers can be changes according to customers' requirements.
The layout of each inlet/outlet branches adopts divergent design, which effectively avoids the risk of cross contamination of samples from different branches.
| Names | BPHD Access | |||
|---|---|---|---|---|
| Pump Heads | 0.05~1 L/min | 0.15~3 L/min | 0.5~10 L/min | 1~20 L/min |
| Corresponding Paths | 3/16” | 1/4” | 3/8” | 5/8” |
| Pumps | Single pump / Double pumps | |||
| Inlets | 4 inlets per pump or customized | |||
| Air Trap | Inline / Bypass, equipped with high & low level gauges | |||
| Columns | Downflow / Upflow / Bypass; 1 column position | |||
| Outlets | 4 outlets or customized | |||
| Pressure Sensors | Pump pressure / Pre-column pressure | |||
| pH Range | 0~14 | |||
| Conductivity Range | 0~300 mS/cm / 0~500 mS/cm | |||
| UV Detecter | 200~400 nm; fixed single wavelength or variable dual wavelengthes | |||
| Operating Pressure Max. | 4bar | |||
| Software | Puriver™ | |||
2C-PCC and 3C-PCC are optional to meet different process requirements.
Both lab-scale and production-scale systems can be provided to facilitate process amplification.
Production-scale system pipeline adopts symmetrical design to ensure the same length of each flow path to the greatest extent.
Reasonable operation logic ensures that there is no sample residue in the pipeline after each cycle.
Method editor function is flexible, sets of method templates are provided.
The functions of overlapping components recovery and purification and trace components enrichment can be expanded.
About the comparison between 2C-PCC and 3C-PCC, productivity is most important, that is, the yield of per unit volume resin in per unit time.
The sample loading time of different processes is different. If the sample loading time is long, the productivity of 2C-PCC is higher than that of 3C-PCC; If the sample loading time is short, the productivity of 3C-PCC is
higher than that of 2C-PCC.
| Names | BPHD PCC Lab 050 |
BPHD PCC Lab 100 |
BPHD PCC Pro 03 |
BPHD PCC Pro 10 |
BPHD PCC Pro 20 |
|---|---|---|---|---|---|
| Flow Rate | 0.1~50 ml/min | 0.1~100 ml/min | 0.10~3 L/min | 0.26~10 L/min | 1~20 L/min |
| Pipe I.D.(mm) | 1/16“ + 1/8” | 1/16“ + 1/8” | 6 | 10 | 15 |
| Pumps | Double pumps | ||||
| Number of Columns | 2 or 3 | ||||
| Functions | Batch / 2C-PCC / 3C-PCC | ||||
| pH Range | 0~14 | ||||
| Conductivity Range | 0~300 mS/cm/0~500/mS/cm | ||||
| UV Detecters | 200~400 nm; fixed single wavelength or variable dual wavelengthes | ||||
| Software | Puriver™ | ||||
Column sealing structure is stable and reliable, easy to maintain.
Column head can be rotated easily, the operation is more convenient.
The sieve plates are SS sintered meshes, much easier to remove bubbles.
Glass, acrylic and SS are optional materials for column tube.
Sanitary grade materials, fully meet the requirements of GMP regulations.
| Names | MC 100-500 | MC 140-500 | MC 200-500 | MC 300-500 | MC 450-500 |
|---|---|---|---|---|---|
| I.D. (mm) | 100 | 140 | 200 | 296 | 446 |
| Tube Height(mm) | 500 | 500 | 500 | 500 | 500 |
| Cross Section Area(cm2) | 78.5 | 154 | 314 | 688 | 1561 |
| Bed Height(mm) | 50~300 | 50~300 | 50~300 | 50~300 | 50~300 |
| Bed Volume(L) | 0.4~2.4 | 0.8~4.6 | 1.6~9.5 | 3.5~20.6 | 7.8~46.8 |
| Protection Class | IP65 | ||||
| Wetted Materials | SS, PP, EPDM | ||||
| Names | MC 100-950 | MC 140-950 | MC 200-950 | MC 300-950 | MC 450-950 |
|---|---|---|---|---|---|
| I.D. (mm) | 100 | 140 | 200 | 296 | 446 |
| Tube Height(mm) | 950 | 950 | 950 | 950 | 950 |
| Cross Section Area(cm2) | 78.5 | 154 | 314 | 688 | 1561 |
| Bed Height(mm) | 550~700 | 550~700 | 550~700 | 550~700 | 550~700 |
| Bed Volume(L) | 4.3~5.5 | 8.5~10.8 | 17.3~22.0 | 37.8~48.2 | 85.8~109.3 |
| Protection Class | IP65 | ||||
| Wetted Materials | SS, PP, EPDM | ||||
*Extender is optional to meet special use requirements.
Motor controls column head lifting, which makes resin compression process more stable and saves labor.
Pressure sensor can be equipped to monitor the pressure in the column in real time to prevent overpressure.
The column tube can be tilted and rotated, which is convenient for unpacking resin and cleaning column tube.
Slide rail is equipped, which is convenient for transferring column position and packing/unpacking resin.
Sanitary grade materials, fully meet the requirements of GMP regulations.
| Names | EMC 100-500 | EMC 140-500 | EMC 200-500 | EMC 300-500 | EMC 450-500 |
|---|---|---|---|---|---|
| I.D. (mm) | 100 | 140 | 200 | 296 | 446 |
| Tube Height(mm) | 500 | 500 | 500 | 500 | 500 |
| Cross Section Area（cm2） | 78.5 | 154 | 314 | 688 | 1561 |
| Bed Height(mm) | 50~300 | 50~300 | 50~300 | 50~300 | 50~300 |
| Bed Volume(L) | 0.4~2.4 | 0.8~4.6 | 1.6~9.5 | 3.5~20.6 | 7.8~46.8 |
| Protection Class | IP65 | ||||
| Wetted Materials | SS, PP, EPDM | ||||
| Names | EMC 100-950 | EMC 140-950 | EMC 200-950 | EMC 300-950 | EMC 450-950 |
|---|---|---|---|---|---|
| I.D. (mm) | 100 | 140 | 200 | 296 | 446 |
| Tube Height(mm) | 950 | 950 | 950 | 950 | 950 |
| Cross Section Area（cm2） | 78.5 | 154 | 314 | 688 | 1561 |
| Bed Height(mm) | 550~700 | 550~700 | 550~700 | 550~700 | 550~700 |
| Bed Volume(L) | 4.3~5.5 | 8.5~10.8 | 17.3~22.0 | 37.8~48.2 | 85.8~109.3 |
| Protection Class | IP65 | ||||
| Wetted Materials | SS, PP, EPDM | ||||
*Extender is optional to meet special use requirements.
Automatic column packing by either pumping or sucking resin.
Packing wizard and Unpacking wizard are convenient and humanized.
Professional distributor design ensures uniform liquid distribution.
The sieve plates are SS sintered meshes,easy to remove bubbles.
Double O-rings are used for sealing so as to realize more reliability.
The packing performances are stable and can ensure good reproducibility.
Meet customized requirements, 800mm is an optional column height value.
The design fully meets the requirements of GMP regulations and IQ / OQ service can be provided perfectly.
| Names | ALC 0450-550 | ALC 0630-550 | ALC 0800-550 | ALC 1000-550 | ALC 1200-550 |
|---|---|---|---|---|---|
| I.D. (mm) | 446 | 630 | 800 | 1000 | 1200 |
| Tube Height(mm) | 550 | 550 | 550 | 550 | 550 |
| Cross Section Area(cm2) | 1561 | 3116 | 5024 | 7850 | 11304 |
| Bed Height(mm) | 50~350 | 50~350 | 50~350 | 50~350 | 50~350 |
| Bed Volume(L) | 7.8~55 | 15.6~109 | 25.1~176 | 39.3~274.8 | 56.5~395.6 |
| Protection Class | IP65 | ||||
| Wetted Materials | SS, Acrylic, PP, EPDM | ||||
High precision, low pulse, wide flow rate range and stable performance.
It can match different detectors, such as UV detector, RI detector and ELSD.
The chromatographic software is powerful, easy to set parameters, edit methods and generate reports.
Analytical specifications can also be provided, high cost performance, which is the first choice for users of universities and scientific research institutes.
| Names | F1 0010 | F1 0050 | F1 0100 | F1 0300 | F1 0600 | F1 1000 | F1 3000 |
|---|---|---|---|---|---|---|---|
| Flow Rate(ml/min) | 0.001～9.999 | 0.01～49.99 | 0.01～99.99 | 0.01～299.99 | 0.01～599.99 | 0.01～999.99 | 0.01～2999.99 |
| Single Pass Discharge Volume (μl) | 28.5 | 120 | 240 | 700 | 1560 | 3060 | 11600 |
| Operating Pressure Max. (bar) | 420 | 300 | 200 | 150 | 150 | 100 | 100 |
| Pumps | Single pump / Double pumps | ||||||
| Detector Types | UV detector / RI detector / ELSD | ||||||
| Control Modes | Panel control, or computer control | ||||||
Compact structure, convenient operation, meets the requirements of GMP regulations.
Good reproducibility and high column efficiency, easy for linear amplification.
The unique distributor design refines the H-tree to more than eight classes to avoid sample diffusion and ensure column efficiency.
The bottom collector provides the shortest flow paths, reduces dead volume, and avoids tailing phenomenon.
Pneumatic pressure control conforms to special explosion-proof operation environment requirements.
The dynamic seal design of pressurized piston body adopts redundant double seal to ensure zero leakage of piston.
It is suitable for purification of polypeptide drugs, synthetic drugs and natural products from lab-scale to production-scale.
| Names | Descriptions |
|---|---|
| Materials | The wetted parts are 316L SS, the non-wetted parts are 304 SS. |
| I.D. (mm) | 50 80 100 150 200 300 400 450 500 600 800 1000 1100 1200 |
| Roughness of Internal Wall | Ra≤0.2 |
| Tube Height | 650mm or customized |
| Siece Plate | Material: 316L SS, aperture: 3-10μm |
| Distributor | Material: 316L SS, distribution model: H-TREE |
| Pneumatic Oil Pump | Maximum pressure: 320 bar |
| Operating Pressure Max. | 100 bar |
| Air Pressure | 6-8 bar |
| Control Panel | Includes: gas pressure meter, oil pressure meter, gas pressure regulator, reversing valve, etc. |
It is suitable for stirring resin slurry and exchanging storage solution.
It is convenient to adjust the slurry concentration and ensure the controllability of column packing process.
Stir with low shear force to ensure that the resin is not damaged.
Movable design, equipped with weighing module and spray ball for easy operation and maintenance.
| Names | Descriptions |
|---|---|
| Wetted Materials | 316L SS |
| Roughness of Internal Wall | Ra≤0.4 |
| Tank Volume | Customized |
| System Configuration | Equipped with weighing module, spray ball and control cabinet |
| Matched Columns | BPHD MC columns, BPHD EMC columns, BPHD ALC columns, etc |
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sales@dashihe.tech (pre-sales consulting) help@dashihe.tech (after-sales consulting)
Company Address: Life Science Park, Changping District, Beijing Hotline: 400-006-8849